The Negative Regulative Roles of BdPGRPs in the Imd Signaling Pathway of Bactrocera dorsalis.

ABSTRACT: Peptidoglycan recognition proteins (PGRPs) are key regulators in insects' immune response, functioning as sensors to detect invading pathogens and as scavengers of peptidoglycan (PGN) to reduce immune overreaction. However, the exact function of PGRPs in Bactrocera dorsalis is still unclear. In this study, we identified and functionally characterized the genes BdPGRP-LB, BdPGRP-SB₁ and BdPGRP-SC₂ in B. dorsalis. The results showed that BdPGRP-LB, BdPGRP-SB₁ and BdPGRP-SC₂ all have an amidase-2 domain, which has been shown to have N-Acetylmuramoyl-l-Alanine amidase activity. The transcriptional levels of BdPGRP-LB and BdPGRP-SC₂ were both high in adult stages a

SUBMITTER: Zhang P 

PROVIDER: S-EPMC8750024 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature