Oxygen-Dependent Changes in the N-Glycome of Murine Pulmonary Endothelial Cells.

ABSTRACT: Supplemental oxygen is frequently used together with mechanical ventilation to achieve sufficient blood oxygenation. Despite the undoubted benefits, it is vigorously debated whether too much oxygen can also have unpredicted side-effects. Uncertainty is also due to the fact that the molecular mechanisms are still insufficiently understood. The lung endothelium is covered with an exceptionally broad glycocalyx, carrying N- and O-glycans, proteoglycans, glycolipids and glycosaminoglycans. Glycan structures are not genetically determined but depend on the metabolic state and the expression level and activity of biosynthetic and glycan remodeling enzymes, which can be influenced by oxygen and the redox status of the cell. Altered glycan structures can affect cell interactions and signaling. In

SUBMITTER: Tiboldi A 

PROVIDER: S-EPMC8750181 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature