Ontology highlight
ABSTRACT:
SUBMITTER: Gomes INF
PROVIDER: S-EPMC8750399 | biostudies-literature | 2022 Jan
REPOSITORIES: biostudies-literature
Gomes Izabela N F INF da Silva-Oliveira Renato J RJ da Silva Luciane Sussuchi LS Martinho Olga O Evangelista Adriane F AF van Helvoort Lengert André A Leal Letícia Ferro LF Silva Viviane Aline Oliveira VAO Dos Santos Stéphanie Piancenti SP Nascimento Flávia Caroline FC Lopes Carvalho André A Reis Rui Manuel RM
Cells 20220104 1
Cetuximab is the sole anti-EGFR monoclonal antibody that is FDA approved to treat head and neck squamous cell carcinoma (HNSCC). However, no predictive biomarkers of cetuximab response are known for HNSCC. Herein, we address the molecular mechanisms underlying cetuximab resistance in an in vitro model. We established a cetuximab resistant model (FaDu), using increased cetuximab concentrations for more than eight months. The resistance and parental cells were evaluated for cell viability and func ...[more]