Myeloid-Derived Suppressor Cells in Prostate Cancer: Present Knowledge and Future Perspectives.

ABSTRACT: Several lines of research are being investigated to better understand mechanisms implicated in response or resistance to immune checkpoint blockade in prostate cancer (PCa). Myeloid-derived suppressor cells (MDSCs) have emerged as a major mediator of immunosuppression in the tumor microenvironment that promotes progression of various tumor types. The main mechanisms underlying MDSC-induced immunosuppression are currently being explored and strategies to enhance anti-tumor immune response via MDSC targeting are being tested. However, the role of MDSCs in PCa remains elusive. In this review, we aim to summarize and present the state-of-the-art knowledge on current methodologies to phenotypically and metabolically characterize MDSCs in PCa. We describe how these characteristics may be linked

SUBMITTER: Koinis F 

PROVIDER: S-EPMC8750906 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature