Ontology highlight
ABSTRACT:
SUBMITTER: Pedersen TB
PROVIDER: S-EPMC8751348 | biostudies-literature | 2022 Jan
REPOSITORIES: biostudies-literature
Pedersen Tobias Bruun TB Nielsen Mikkel Rank MR Kristensen Sebastian Birkedal SB Spedtsberg Eva Mie Lang EML Sørensen Trine T Petersen Celine C Muff Jens J Sondergaard Teis Esben TE Nielsen Kåre Lehmann KL Wimmer Reinhard R Gardiner Donald Max DM Sørensen Jens Laurids JL
Microbial cell factories 20220110 1
The biosynthetic pathways for the fungal polyketides bikaverin and bostrycoidin, from Fusarium verticillioides and Fusarium solani respectively, were reconstructed and heterologously expressed in S. cerevisiae alongside seven different phosphopantetheinyl transferases (PPTases) from a variety of origins spanning bacterial, yeast and fungal origins. In order to gauge the efficiency of the interaction between the ACP-domains of the polyketide synthases (PKS) and PPTases, each were co-expressed ind ...[more]