Unknown

Dataset Information

0

Cell-Free Mitochondrial DNA as a Potential Biomarker for Astronauts' Health.


ABSTRACT: Background Space travel-associated stressors such as microgravity or radiation exposure have been reported in astronauts after short- and long-duration missions aboard the International Space Station. Despite risk mitigation strategies, adverse health effects remain a concern. Thus, there is a need to develop new diagnostic tools to facilitate early detection of physiological stress. Methods and Results We measured the levels of circulating cell-free mitochondrial DNA in blood plasma of 14 astronauts 10 days before launch, the day of landing, and 3 days after return. Our results revealed a significant increase of cell-free mitochondrial DNA in the plasma on the day of landing and 3 days after return with vast ~2 to 355-fold interastronaut variability. In addition, gene expression analysis of peripheral blood mononuclear cells revealed a significant increase in markers of inflammation, oxidative stress, and DNA damage. Conclusions Our study suggests that cell-free mitochondrial DNA abundance might be a biomarker of stress or immune response related to microgravity, radiation, and other environmental factors during space flight.

SUBMITTER: Bisserier M 

PROVIDER: S-EPMC8751818 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC6375341 | biostudies-literature
| S-EPMC6419393 | biostudies-literature
| S-EPMC10287154 | biostudies-literature
| S-EPMC6076378 | biostudies-other
| S-EPMC7290331 | biostudies-literature
| S-EPMC6031238 | biostudies-literature
| S-EPMC6351822 | biostudies-literature
| 2633274 | ecrin-mdr-crc
| S-EPMC8005001 | biostudies-literature
| S-EPMC7827757 | biostudies-literature