Unknown

Dataset Information

0

Synthesis of Two Stereoisomers of Potentially Bioactive 13,19,20-Trihydroxy Derivative of Docosahexaenoic Acid.


ABSTRACT: The C16-C22 fragment with the acetylene terminus was constructed through the asymmetric dihydroxylation of the corresponding olefin, while the 15-iodo-olefin corresponding to the C11-C15 part was prepared via the asymmetric transfer hydrogenation of the corresponding acetylene ketone followed by hydrozirconation/iodination. Both pieces were joined by a Sonogashira coupling, and the product was further converted into the title compound via a Wittig reaction with the remaining C1-C10 segment and Boland reduction using Zn with TMSCl.

SUBMITTER: Ogawa N 

PROVIDER: S-EPMC8752060 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC7944941 | biostudies-literature
| S-EPMC2975720 | biostudies-literature
| S-EPMC8759201 | biostudies-literature
| S-EPMC7606508 | biostudies-literature
| S-EPMC4737532 | biostudies-literature
| S-EPMC11002926 | biostudies-literature
| S-EPMC6923955 | biostudies-literature
| S-EPMC3678760 | biostudies-literature
| S-EPMC7330081 | biostudies-literature
| S-EPMC8706101 | biostudies-literature