Dataset Information

Antibiotic Use and Presumptive Pathogens in the Veterans Affairs Healthcare System.

ABSTRACT:

Background

Empirical antibiotic use is common in the hospital. Here, we characterize patterns of antibiotic use, infectious diagnoses, and microbiological laboratory results among hospitalized patients and aim to quantify the proportion of antibiotic use that is potentially attributable to specific bacterial pathogens.

Methods

We conducted an observational study using electronic health records from acute care facilities in the US Veterans Affairs Healthcare System. From October 2017 to September 2018, 482 381 hospitalizations for 332 657 unique patients that met all criteria were included. At least 1 antibiotic was administered at 202 037 (41.9%) of included hospital stays. We measured frequency of antibiotic use, microbiological specimen collection, and bacterial isolation by diagnosis category and antibiotic group. A tiered system based on specimen collection sites and diagnoses was used to attribute antibiotic use to presumptive causative organisms.

Results

Specimens were collected at 130 012 (64.4%) hospitalizations with any antibiotic use, and at least 1 bacterial organism was isolated at 35.1% of these stays. Frequency of bacterial isolation varied widely by diagnosis category and antibiotic group. Under increasingly lenient criteria, 10.2%-31.4% of 974 733 antibiotic days of therapy could be linked to a potential bacterial pathogen.

Conclusions

Overall, the vast majority of antibiotic use could be linked to either an infectious diagnosis or microbiological specimen. Nearly one-half of antibiotic use occurred when there was a specimen collected but no bacterial organism identified, underscoring the need for rapid and improved diagnostics to optimize antibiotic use.

SUBMITTER: Tedijanto C

PROVIDER: S-EPMC8752245 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature

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Publications

Antibiotic Use and Presumptive Pathogens in the Veterans Affairs Healthcare System.

Tedijanto Christine C Nevers McKenna M Samore Matthew H MH Lipsitch Marc M

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20220101 1

<h4>Background</h4>Empirical antibiotic use is common in the hospital. Here, we characterize patterns of antibiotic use, infectious diagnoses, and microbiological laboratory results among hospitalized patients and aim to quantify the proportion of antibiotic use that is potentially attributable to specific bacterial pathogens.<h4>Methods</h4>We conducted an observational study using electronic health records from acute care facilities in the US Veterans Affairs Healthcare System. From October 20 ...[more]

PMID: 33621326

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Dataset Information

Antibiotic Use and Presumptive Pathogens in the Veterans Affairs Healthcare System.

Background

Methods

Results

Conclusions

Publications

Antibiotic Use and Presumptive Pathogens in the Veterans Affairs Healthcare System.

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