Associations between genetic loci, environment factors and mental disorders: a genome-wide survival analysis using the UK Biobank data.

ABSTRACT: It is well-accepted that both environment and genetic factors contribute to the development of mental disorders (MD). However, few genetic studies used time-to-event data analysis to identify the susceptibility genetic variants associated with MD and explore the role of environment factors in these associations. In order to detect novel genetic loci associated with MD based on the time-to-event data and identify the role of environmental factors in them, this study recruited 376,806 participants from the UK Biobank cohort. The MD outcomes (including overall MD status, anxiety, depression and substance use disorders (SUD)) were defined based on in-patient hospital, self-reported and death registry data collected in the UK Biobank. SPACOX approach was used to identify the susceptibility loci

SUBMITTER: Meng P 

PROVIDER: S-EPMC8752606 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature