Maternal high-fat diet in mice induces cerebrovascular, microglial and long-term behavioural alterations in offspring.

ABSTRACT: Various environmental exposures during pregnancy, like maternal diet, can compromise, at critical periods of development, the neurovascular maturation of the offspring. Foetal exposure to maternal high-fat diet (mHFD), common to Western societies, has been shown to disturb neurovascular development in neonates and long-term permeability of the neurovasculature. Nevertheless, the effects of mHFD on the offspring's cerebrovascular health remains largely elusive. Here, we sought to address this knowledge gap by using a translational mouse model of mHFD exposure. Three-dimensional and ultrastructure analysis of the neurovascular unit (vasculature and parenchymal cells) in mHFD-exposed offspring revealed major alterations of the neurovascular organization and metabolism. These alterations were

SUBMITTER: Bordeleau M 

PROVIDER: S-EPMC8752761 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature