Reassessing the evidence for universal school-age BCG vaccination in England and Wales: re-evaluating and updating a modelling study.

ABSTRACT:

Objectives

In 2005, England and Wales switched from universal BCG vaccination against tuberculosis (TB) disease for school-age children to targeted vaccination of neonates. We aimed to recreate and re-evaluate a previously published model, the results of which informed this policy change.

Design

We recreated an approach for estimating the impact of ending the BCG schools scheme, correcting a methodological flaw in the model, updating the model with parameter uncertainty and improving parameter estimates where possible. We investigated scenarios for the assumed annual decrease in TB incidence rates considered by the UK's Joint Committee on Vaccination and Immunisation and explored alternative scenarios using notification data.

Setting

England and Wales.

Outcome meas

SUBMITTER: Abbott S 

PROVIDER: S-EPMC8753396 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature