21st Century Cures Act, an Information Technology-Led Organizational Initiative.
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ABSTRACT:
SUBMITTER: Magid SK
PROVIDER: S-EPMC8753555 | biostudies-literature |
REPOSITORIES: biostudies-literature
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Project description: Not available
| S-EPMC8184485 | biostudies-literature
Project description:The ongoing agrarian transition from small-holder farming to large-scale commercial agriculture is reshaping systems of production and human well-being in many regions. A fundamental part of this global transition is manifested in large-scale land acquisitions (LSLAs) by agribusinesses. Its energy implications, however, remain poorly understood. Here, we assess the multi-dimensional changes in fossil-fuel-based energy demand resulting from this agrarian transition. We focus on LSLAs by comparing two scenarios of low-input and high-input agricultural practices, exemplifying systems of production in place before and after the agrarian transition. A shift to high-input crop production requires industrial fertilizer application, mechanization of farming practices and irrigation, which increases by ~5 times fossil-fuel-based energy consumption compared to low-input agriculture. Given the high energy and carbon footprints of LSLAs and concerns over local energy access, our analysis highlights the need for an approach that prioritizes local resource access and incorporates energy-intensity analyses in land use governance.
| S-EPMC8055646 | biostudies-literature
Project description:Sand seas are vast expanses of Earth's surface containing large areas of aeolian dunes-topographic patterns manifest from above-threshold winds and a supply of loose sand. Predictions of the role of future climate change for sand-sea activity are sparse and contradictory. Here we examine the impact of climate on all of Earth's presently-unvegetated sand seas, using ensemble runs of an Earth System Model for historical and future Shared Socioeconomic Pathway (SSP) scenarios. We find that almost all of the sand seas decrease in activity relative to present-day and industrial-onset for all future SSP scenarios, largely due to more intermittent sand-transport events. An increase in event wait-times and decrease in sand transport is conducive to vegetation growth. We expect dune-forming winds will become more unimodal, and produce larger incipient wavelengths, due to weaker and more seasonal winds. Our results indicate that these qualitative changes in Earth's deserts cannot be mitigated.
| S-EPMC9237066 | biostudies-literature
Project description:Greenspace plays a crucial role in urban ecosystems and has been recognized as a key factor in promoting sustainable and healthy city development. Recent studies have revealed a growing concern about urban greenspace exposure inequality; however, the extent to which urbanization affects human exposure to greenspace and associated inequalities over time remains unclear. Here, we incorporate a Landsat-based 30-meter time-series greenspace mapping and a population-weighted exposure framework to quantify the changes in human exposure to greenspace and associated equality (rather than equity) for 1028 global cities from 2000 to 2018. Results show a substantial increase in physical greenspace coverage and an improvement in human exposure to urban greenspace, leading to a reduction in greenspace exposure inequality over the past two decades. Nevertheless, we observe a contrast in the rate of reduction in greenspace exposure inequality between cities in the Global South and North, with a faster rate of reduction in the Global South, nearly four times that of the Global North. These findings provide valuable insights into the impact of urbanization on urban nature and environmental inequality change and can help inform future city greening efforts.
| S-EPMC10575899 | biostudies-literature
Project description:Advances in geroscience are allowing scientists and clinicians, for the first time, to consider interventions aimed at directly targeting the hallmarks of aging. Unlike disease-specific approaches, such interventions have the potential to prevent multiple diseases of aging simultaneously, thereby greatly enhancing healthspan for most individuals. Initial clinical data indicates that geroprotective compounds such as rapamycin and metformin may be effective at delaying or reversing age-related disease in otherwise healthy elderly people and companion animals. Here I will provide an overview of the field of translational geroscience, which I believe will become the paradigm for the practice of medicine in the 21st century.
| S-EPMC7098696 | biostudies-literature
Project description: Not available
| S-EPMC9732606 | biostudies-literature
Project description:As agricultural regions are threatened by climate change, warming of high latitude regions and increasing food demands may lead to northward expansion of global agriculture. While socio-economic demands and edaphic conditions may govern the expansion, climate is a key limiting factor. Extant literature on future crop projections considers established agricultural regions and is mainly temperature based. We employed growing degree days (GDD), as the physiological link between temperature and crop growth, to assess the global northward shift of agricultural climate zones under 21st-century climate change. Using ClimGen scenarios for seven global climate models (GCMs), based on greenhouse gas (GHG) emissions and transient GHGs, we delineated the future extent of GDD areas, feasible for small cereals, and assessed the projected changes in rainfall and potential evapotranspiration. By 2099, roughly 76% (55% to 89%) of the boreal region might reach crop feasible GDD conditions, compared to the current 32%. The leading edge of the feasible GDD will shift northwards up to 1200?km by 2099 while the altitudinal shift remains marginal. However, most of the newly gained areas are associated with highly seasonal and monthly variations in climatic water balances, a critical component of any future land-use and management decisions.
| S-EPMC5962595 | biostudies-literature
Project description:Surface Temperature (ST) over India has increased by ~0.055?K/decade during 1860-2005 and follows the global warming trend. Here, the natural and external forcings (e.g., natural and anthropogenic) responsible for ST variability are studied from Coupled Model Inter-comparison phase 5 (CMIP5) models during the 20th century and projections during the 21st century along with seasonal variability. Greenhouse Gases (GHG) and Land Use (LU) are the major factors that gave rise to warming during the 20th century. Anthropogenic Aerosols (AA) have slowed down the warming rate. The CMIP5 projection over India shows a sharp increase in ST under Representative Concentration Pathways (RCP) 8.5 where it reaches a maximum of 5?K by the end of the 21st century. Under RCP2.6 emission scenarios, ST increases up to the year 2050 and decreases afterwards. The seasonal variability of ST during the 21st century shows significant increase during summer. Analysis of rare heat and cold events for 2080-2099 relative to a base period of 1986-2006 under RCP8.5 scenarios reveals that both are likely to increase substantially. However, by controlling the regional AA and LU change in India, a reduction in further warming over India region might be achieved.
| S-EPMC5462738 | biostudies-literature
Project description:Drylands are home to over 2 billion people globally, many of whom use the land for agricultural and pastoral activities. These vulnerable livelihoods could be disrupted if desert dunefields become more active in response to climate and land use change. Despite increasing knowledge about the role that wind, moisture availability and vegetation cover play in shaping dryland landscapes, relatively little is known about how drylands might respond to climatic and population pressures over the 21st century. Here we use a newly developed numerical model, which fully couples vegetation and sediment-transport dynamics, to simulate potential landscape evolution at three locations in the Kalahari Desert, under two future emissions scenarios: stabilising (RCP 4.5) and high (RCP 8.5). Our simulations suggest that whilst our study sites will experience some climatically-induced landscape change, the impacts of climate change alone on vegetation cover and sediment mobility may be relatively small. However, human activity could strongly exacerbate certain landscape trajectories. Fire frequency has a primary impact on vegetation cover, and, together with grazing pressure, plays a significant role in modulating shrub encroachment and ensuing land degradation processes. Appropriate land management strategies must be implemented across the Kalahari Desert to avoid severe environmental and socio-economic consequences over the coming decades.
| S-EPMC5478674 | biostudies-literature
Project description:Mountain glaciers are known to be strongly affected by global climate change. Here we compute temporally consistent changes in glacier area, surface elevation and ice mass over the entire European Alps between 2000 and 2014. We apply remote sensing techniques on an extensive database of optical and radar imagery covering 93% of the total Alpine glacier volume. Our results reveal rapid glacier retreat across the Alps (-39?km²?a-1) with regionally variable ice thickness changes (-0.5 to -0.9?m?a-1). The strongest downwasting is observed in the Swiss Glarus and Lepontine Alps with specific mass change rates up to -1.03?m.w.e.?a-1. For the entire Alps a mass loss of 1.3?±?0.2?Gt?a-1 (2000-2014) is estimated. Compared to previous studies, our estimated mass changes are similar for the central Alps, but less negative for the lower mountain ranges. These observations provide important information for future research on various socio-economic impacts like water resource management, risk assessments and tourism.
| S-EPMC7316704 | biostudies-literature