Protein Nutritional Status and Frailty: A Mendelian Randomization Study.

ABSTRACT:

Background

Observational studies have suggested that better protein nutritional status may contribute to prevention of frailty.

Objective

We sought to examine this hypothesis using a Mendelian randomization (MR) analysis.

Methods

We conducted a two-sample MR study using GWAS summary statistics data of the UK Biobank. We applied genetically predicted serum albumin as a primary exposure measure and serum total protein as a secondary exposure measure. The outcome measure was the Rockwood frailty index (FI) based on 49 deficits from 356,432 individuals (53.3% of them were women, with a mean ± SD age of 56.7 ± 8.0 y. The association between serum protein measures and FI was mainly analyzed by use of the inverse variance weighted method.

Results

A genetically predict

SUBMITTER: Tomata Y 

PROVIDER: S-EPMC8754580 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature