Dataset Information

Early-death weeks associated with COVID-19: a comparison among France, the UK and the USA.

ABSTRACT: Years of life lost (YLL) is recently used as a more insightful indicator to assess the mortality impact of COVID-19. However, this indicator still has methodological limits. This study aims to propose an alternative approach and new index, early-death weeks. The natural mortality and social mortality laws were employed to support two essential assumptions: the sequential and translational early-mortality patterns of COVID-19. This approach was then used with the data related to COVID-19 to calculate early-death weeks associated with COVID-19 in France, the UK and the USA. As of week 20 of 2021, the rate of the total number of early-death weeks per the population of the USA is nearly two times compared to that of France and the UK, with 0.004% to 0.0021 and 0.0023%, respectively. The average numbers of early-death weeks after converting to units of years are 1.2, 1.0 and 1.3 years in France, the UK and the USA, respectively. The new approach is significantly different from death counts, excess deaths and YLL. The early-death week index provides more insights into COVID-19 and can be applied promptly at any time as well as anywhere once excess deaths have occurred.

SUBMITTER: Cuong VM

PROVIDER: S-EPMC8755315 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature

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Early-death weeks associated with COVID-19: a comparison among France, the UK and the USA.

Cuong Vu Manh VM

Journal of public health (Oxford, England) 20230301 1

<h4>Background</h4>Years of life lost (YLL) is recently used as a more insightful indicator to assess the mortality impact of COVID-19. However, this indicator still has methodological limits. This study aims to propose an alternative approach and new index, early-death weeks.<h4>Methods</h4>The natural mortality and social mortality laws were employed to support two essential assumptions: the sequential and translational early-mortality patterns of COVID-19. This approach was then used with the ...[more]

PMID: 34929732

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Project description:BackgroundFrailty has been associated with worse prognosis following COVID-19 infection. While several studies have reported the association between frailty and COVID-19 mortality or length of hospital stay, there have been no community-based studies on the association between frailty and risk of severe infection. Considering that different definitions have been identified to assess frailty, this study aimed to compare the association between frailty and severe COVID-19 infection in UK Biobank using two frailty classifications: the frailty phenotype and the frailty index.MethodsA total of 383,845 UK Biobank participants recruited 2006-2010 in England (211,310 [55.1%] women, baseline age 37-73 years) were included. COVID-19 test data were provided by Public Health England (available up to 28 June 2020). An adapted version of the frailty phenotype derived by Fried et al. was used to define frailty phenotype (robust, pre-frail, or frail). A previously validated frailty index was derived from 49 self-reported questionnaire items related to health, disease and disability, and mental wellbeing (robust, mild frailty, and moderate/severe frailty). Both classifications were derived from baseline data (2006-2010). Poisson regression models with robust standard errors were used to analyse the associations between both frailty classifications and severe COVID-19 infection (resulting in hospital admission or death), adjusted for sociodemographic and lifestyle factors.ResultsOf UK Biobank participants included, 802 were admitted to hospital with and/or died from COVID19 (323 deaths and 479 hospitalisations). After analyses were adjusted for sociodemographic and lifestyle factors, a higher risk of COVID-19 was observed for pre-frail (risk ratio (RR) 1.47 [95% CI 1.26; 1.71]) and frail (RR 2.66 [95% CI 2.04; 3.47]) individuals compared to those classified as robust using the frailty phenotype. Similar results were observed when the frailty index was used (RR mildly frail 1.46 [95% CI 1.26; 1.71] and RR moderate/severe frailty 2.43 [95% CI 1.91; 3.10]).ConclusionsFrailty was associated with a higher risk of severe COVID-19 infection resulting in hospital admission or death, irrespective of how it was measured and independent of sociodemographic and lifestyle factors. Public health strategies need to consider the additional risk that COVID-19 poses in individuals with frailty, including which additional preventive measures might be required.

Project description:BackgroundIndividual perceptions of personal and national threats posed by COVID-19 shaped initial response to the pandemic. The aim of this study was to investigate the changes in residents' awareness about COVID-19 and to characterize those who were more aware and responsive during the early stages of the pandemic in Louisiana.MethodsIn response to the mounting threat of COVID-19, we added questions to an ongoing food preference study held at Louisiana State University from March 3rd through March 12th, 2020. We asked how likely it was that the spread of the coronavirus will cause a national public health crisis and participants' level of concern about contracting COVID-19 by attending campus events. We used regression and classification tree analysis to identify correlations between these responses and (a) national and local COVID case counts; (b) personal characteristics and (c) randomly assigned information treatments provided as part of the food preference study.ResultsWe found participants expressed a higher likelihood of an impending national crisis as the number of national and local confirmed cases increased. However, concerns about contracting COVID-19 by attending campus events rose more slowly in response to the increasing national and local confirmed case count. By the end of this study on March 12th, 2020 although 89% of participants agreed that COVID-19 would likely cause a public health crisis, only 65% of the participants expressed concerns about contracting COVID-19 from event attendance. These participants were significantly more likely to be younger students, in the highest income group, and to have participated in the study by responding to same-day, in-person flyer distribution.ConclusionsThese results provide initial insights about the perceptions of the COVID-19 public health crisis during its early stages in Louisiana. We concluded with suggestions for universities and similar institutions as in-person activities resume in the absence of widespread vaccination.

Dataset Information

Early-death weeks associated with COVID-19: a comparison among France, the UK and the USA.

Publications

Early-death weeks associated with COVID-19: a comparison among France, the UK and the USA.

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