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Synthesis, Bioactivity Assessment, and Molecular Docking of Non-sulfonamide Benzimidazole-Derived N-Acylhydrazone Scaffolds as Carbonic Anhydrase-II Inhibitors.

ABSTRACT: This research reports the synthesis of new benzimidazole-derived N-acylhydrazones (NAH), their characterization using various spectroscopic methods, and in vitro evaluation as potent carbonic anhydrase-II inhibitors. Among the target compounds (9-29), few showed higher inhibition than the standard acetazolamide (IC₅₀: 18.6 ± 0.43 μM), for example, compound 9 (IC₅₀: 13.3 ± 1.25 μM), 10 (IC₅₀: 17.2 ± 1.24 μM), 12 (IC₅₀: 14.6 ± 0.62 μM), and 15 (IC₅₀: 14.5 ± 1.05 μM). Molecular docking was performed on the most active compounds, which revealed their binding interactions with the active site of the enzyme, thus supporting the experimental findings.

SUBMITTER: Saadiq M

PROVIDER: S-EPMC8756595 | biostudies-literature |

REPOSITORIES: biostudies-literature

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