Iron in airway macrophages and infective exacerbations of chronic obstructive pulmonary disease.

ABSTRACT:

Background

Excess pulmonary iron has been implicated in the pathogenesis of lung disease, including asthma and COPD. An association between higher iron content in sputum macrophages and infective exacerbations of COPD has previously been demonstrated.

Objectives

To assess the mechanisms of pulmonary macrophage iron sequestration, test the effect of macrophage iron-loading on cellular immune function, and prospectively determine if sputum hemosiderin index can predict infectious exacerbations of COPD.

Methods

Intra- and extracellular iron was measured in cell-line-derived and in freshly isolated sputum macrophages under various experimental conditions including treatment with exogenous IL-6 and hepcidin. Bacterial uptake and killing were compared in the presence or abs

SUBMITTER: Ho T 

PROVIDER: S-EPMC8756761 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature