Ontology highlight
ABSTRACT:
SUBMITTER: Kim Y
PROVIDER: S-EPMC8758941 | biostudies-literature | 2022 Jan
REPOSITORIES: biostudies-literature
Kim Youngju Y Jang Hwanseok H Seo Kyubin K Kim June Hoan JH Lee Boram B Cho Hyo Min HM Kim Hyun Jung HJ Yang Esther E Kim Hyun H Gim Jeong-An JA Park Yongdoo Y Ryu Jae Ryun JR Sun Woong W
Stem cell reports 20211216 1
Human pluripotent stem cells (hPSCs) grow as colonies with epithelial-like features including cell polarity and position-dependent features that contribute to symmetry breaking during development. Our study provides evidence that hPSC colonies exhibit position-dependent differences in apical structures and functions. With this apical difference, edge cells were preferentially labeled with amphipathic dyes, which enabled separation of edge and center cells by fluorescence-activated cell sorting. ...[more]