Ontology highlight
ABSTRACT:
SUBMITTER: Wang BX
PROVIDER: S-EPMC8759707 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Wang Benjamin X BX Wheeler Kelsey M KM Cady Kyle C KC Lehoux Sylvain S Cummings Richard D RD Laub Michael T MT Ribbeck Katharina K
Current biology : CB 20201029 1
Mucus is a densely populated ecological niche that coats all non-keratinized epithelia, and plays a critical role in protecting the human body from infections. Although traditionally viewed as a physical barrier, emerging evidence suggests that mucus can directly suppress virulence-associated traits in opportunistic pathogens including Pseudomonas aeruginosa. However, the molecular mechanisms by which mucus affords this protection are unclear. Here, we show that mucins, and particularly their as ...[more]