Ontology highlight
ABSTRACT:
SUBMITTER: van de Veerdonk FL
PROVIDER: S-EPMC8759782 | biostudies-literature | 2022 Jan
REPOSITORIES: biostudies-literature
van de Veerdonk Frank L FL Renga Giorgia G Pariano Marilena M Bellet Marina M MM Servillo Giuseppe G Fallarino Francesca F De Luca Antonella A Iannitti Rossana G RG Piobbico Danilo D Gargaro Marco M Manni Giorgia G D'Onofrio Fiorella F Stincardini Claudia C Sforna Luigi L Borghi Monica M Castelli Marilena M Pieroni Stefania S Oikonomou Vasileios V Villella Valeria R VR Puccetti Matteo M Giovagnoli Stefano S Galarini Roberta R Barola Carolina C Maiuri Luigi L Della Fazia Maria Agnese MA Cellini Barbara B Talesa Vincenzo Nicola VN Dinarello Charles A CA Costantini Claudio C Romani Luigina L
The Journal of clinical investigation 20220101 2
Autophagy selectively degrades aggregation-prone misfolded proteins caused by defective cellular proteostasis. However, the complexity of autophagy may prevent the full appreciation of how its modulation could be used as a therapeutic strategy in disease management. Here, we define a molecular pathway through which recombinant IL-1 receptor antagonist (IL-1Ra, anakinra) affects cellular proteostasis independently from the IL-1 receptor (IL-1R1). Anakinra promoted H2O2-driven autophagy through a ...[more]