Vitamin D receptor gene polymorphism predicts left ventricular hypertrophy in maintenance hemodialysis.

ABSTRACT:

Background

To verify that the single nucleotide polymorphisms (SNP) of vitamin D receptor (VDR) may lead to genetic susceptibility to left ventricular hypertrophy (LVH), the present study was designed to study four SNPs of VDR associated with LVH in maintenance hemodialysis (MHD) patients of Han nationality.

Methods

120 MHD patients were recruited at Department of Nephrology, Zhongnan Hospital of Wuhan University to analyze the expression of genotype, allele and haplotype of Fok I, Bsm I, Apa I and Taq I in blood samples, and to explore their correlation with blood biochemical indexes and ventricular remodeling.

Results

The results showed that the risks of CVD included gender, dialysis time, heart rate, SBP, glycated hemoglobin, calcium, iPTH and CRP concentration. Mo

SUBMITTER: Liu B 

PROVIDER: S-EPMC8761333 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature