Dataset Information

Comprehensive Analysis of Prognostic Microenvironment-Related Genes in Invasive Breast Cancer.

ABSTRACT: Recent studies reveal that tumor microenvironment contributes to breast cancer (BRCA) development, progression, and therapeutic response. However, the contribution of the tumor microenvironment-related genes in routine diagnostic testing or therapeutic decision making for BRCA remains elusive. Immune/stromal/ESTIMATE scores calculated by the ESTIMATE algorithm quantify immune and stromal components in a tumor, and thus can reflect tumor microenvironment. To investigate the association of the tumor microenvironment-related genes with invasive BRCA prognosis, here we analyzed the immune/stromal/ESTIMATE scores in combination with The Cancer Genome Atlas (TCGA) database in invasive BRCA. We found that immune/stromal/ESTIMATE scores were significantly correlated with the invasive BRCA clinicopathological factors. Based on the immune/stromal/ESTIMATE scores, we extracted a series of differential expression genes (DEGs) related to the tumor microenvironment. Survival analysis was further performed to identify a list of high-frequency DEGs (HF-DEGs), which exhibited prognostic value in invasive BRCA. Importantly, consistent with the results of bioinformatics analysis, immunohistochemistry results showed that high SASH3 expression was associated with a good prognosis in invasive BRCA patients. Our findings suggest that the tumor microenvironment-related HF-DEGs identified in this study have prognostic values and may serve as potential biomarkers and therapeutic targets for invasive BRCA.

SUBMITTER: Shi Y

PROVIDER: S-EPMC8761742 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature

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Comprehensive Analysis of Prognostic Microenvironment-Related Genes in Invasive Breast Cancer.

Shi Yingrong Y Chen Si S Xing Huijuan H Jiang Guanglie G Wu Nan N Liu Qiannan Q Sakamoto Norihiro N Kuno Takayoshi T Sugiura Reiko R Xiao Qinghuan Q Jin Feng F Fang Yue Y Yao Fan F

Frontiers in oncology 20220103

Recent studies reveal that tumor microenvironment contributes to breast cancer (BRCA) development, progression, and therapeutic response. However, the contribution of the tumor microenvironment-related genes in routine diagnostic testing or therapeutic decision making for BRCA remains elusive. Immune/stromal/ESTIMATE scores calculated by the ESTIMATE algorithm quantify immune and stromal components in a tumor, and thus can reflect tumor microenvironment. To investigate the association of the tum ...[more]

PMID: 35047378

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Dataset Information

Comprehensive Analysis of Prognostic Microenvironment-Related Genes in Invasive Breast Cancer.

Publications

Comprehensive Analysis of Prognostic Microenvironment-Related Genes in Invasive Breast Cancer.

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