Visual Field Sensitivity Prediction Using Optical Coherence Tomography Analysis in Hydroxychloroquine Toxicity.

ABSTRACT:

Purpose

This study investigates the association between local retina structure and visual function in a cohort with long-term hydroxychloroquine (HCQ) use.

Methods

The study included 84 participants (54 participants without toxicity and 30 participants with toxicity) with history of chronic HCQ use (14.5 ± 7.4 years) who had testing with spectral-domain optical coherence tomography (SD-OCT) imaging and Humphrey 10-2 visual fields. Optical coherence tomography (OCT) metrics (total and outer retina thickness [TRT and ORT], minimum intensity [MinI], and ellipsoid zone [EZ] loss) were sampled in regions corresponding to visual field test locations. Univariate linear correlations were investigated and a multivariate random forest regression using a combination of OCT metrics was

SUBMITTER: Jayakar G 

PROVIDER: S-EPMC8762675 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature