SMAD4-201 transcript as a putative biomarker in colorectal cancer.

ABSTRACT:

Background

Transcripts with alternative 5'-untranslated regions (UTRs) result from the activity of alternative promoters and they can determine gene expression by influencing its stability and translational efficiency, thus executing complex regulation of developmental, physiological and pathological processes. Transcriptional regulation of human SMAD4, a key tumor suppressor deregulated in most gastrointestinal cancers, entails four alternative promoters. These promoters and alternative transcripts they generate remain unexplored as contributors to the SMAD4 deregulation in cancer. The aim of this study was to investigate the relative abundance of the transcript SMAD4-201 in colorectal cell lines and tissues in order to establish if its fluctuations may be associated with colorect

SUBMITTER: Babic T 

PROVIDER: S-EPMC8762975 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature