Unknown

Dataset Information

0

Immunogenicity of SCB-2019 Coronavirus Disease 2019 Vaccine Compared With 4 Approved Vaccines.


ABSTRACT: A significant correlation has been shown between the binding antibody responses against original severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein and vaccine efficacy of 4 approved coronavirus disease 2019 vaccines. We therefore assessed the immune response against original SARS-CoV-2 elicited by the adjuvanted S-Trimer vaccine, SCB-2019 + CpG/alum, in the same assay and laboratory. Responses to SCB-2019 were comparable or superior for antibody to original and Alpha variant when compared with 4 approved vaccines. The comparison accurately predicted success of the recently reported efficacy trial of SCB-2019 vaccine. Immunogenicity comparisons to original strain and variants of concern should be considered as a basis for authorization of vaccines.

SUBMITTER: Ambrosino D 

PROVIDER: S-EPMC8763959 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC8690024 | biostudies-literature
| S-EPMC10069839 | biostudies-literature
| S-EPMC8499965 | biostudies-literature
| S-EPMC7147283 | biostudies-literature
| S-EPMC7799296 | biostudies-literature
| S-EPMC9760890 | biostudies-literature
| S-EPMC8507598 | biostudies-literature
| S-EPMC10793671 | biostudies-literature
| S-EPMC8805078 | biostudies-literature
| S-EPMC9047246 | biostudies-literature