Robotic stereotaxic system based on 3D skull reconstruction to improve surgical accuracy and speed.

ABSTRACT:

Background

Some experimental approaches in neuroscience research require the precise placement of a recording electrode, pipette or other tool into a specific brain area that can be quite small and/or located deep beneath the surface. This process is typically aided with stereotaxic methods but remains challenging due to a lack of advanced technology to aid the experimenter. Currently, procedures require a significant amount of skill, have a high failure rate, and take up a significant amount of time.

New method

We developed a next generation robotic stereotaxic platform for small rodents by combining a three-dimensional (3D) skull profiler sub-system and a full six degree-of-freedom (6DOF) robotic platform. The 3D skull profiler is based on structured illumination in which

SUBMITTER: Ly PT 

PROVIDER: S-EPMC8764742 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature