Hypothyroidism does not lead to worse prognosis in COVID-19: findings from the Brazilian COVID-19 registry.
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ABSTRACT: Background
It is not clear whether previous thyroid diseases influence the course and outcomes of COVID-19.Methods
The study is a part of a multicentric cohort of patients with confirmed COVID-19 diagnosis from 37 hospitals. Matching for age, sex, number of comorbidities, and hospital was performed for the paired analysis.Results
Of 7,762 patients with COVID-19, 526 had previously diagnosed hypothyroidism and 526 were matched controls. The median age was 70 years, and 68.3% were females. The prevalence of comorbidities was similar, except for coronary and chronic kidney diseases that were higher in the hypothyroidism group (p=0.015 and p=0.001). D-dimer levels were lower in patients with hypothyroid (p=0.037). In-hospital management was similar, but hospital length-of-stay (p=0.029) and mechanical ventilation requirement (p=0.006) were lower for patients with hypothyroidism. There was a trend of lower in-hospital mortality in patients with hypothyroidism (22.1% vs 27.0%; p=0.062).Conclusion
Patients with hypothyroidism had a lower requirement of mechanical ventilation and showed a trend of lower in-hospital mortality. Therefore, hypothyroidism does not seem to be associated with a worse prognosis.
SUBMITTER: Pereira DN
PROVIDER: S-EPMC8769529 | biostudies-literature | 2022 Mar
REPOSITORIES: biostudies-literature
Publications
Hypothyroidism does not lead to worse prognosis in COVID-19: findings from the Brazilian COVID-19 registry.
Pereira Daniella Nunes DN Silveira Leticia Ferreira Gontijo LFG Guimarães Milena Maria Moreira MMM Polanczyk Carísi Anne CA Nunes Aline Gabrielle Sousa AGS Costa André Soares de Moura ASM Farace Barbara Lopes BL Cimini Christiane Corrêa Rodrigues CCR Carvalho Cíntia Alcantara de CA Ponce Daniela D Roesch Eliane Würdig EW Manenti Euler Roberto Fernandes ERF Lucas Fernanda Barbosa FB Rodrigues Fernanda d'Athayde FD Anschau Fernando F Aranha Fernando Graça FG Bartolazzi Frederico F Vietta Giovanna Grunewald GG Nascimento Guilherme Fagundes GF Duani Helena H Vianna Heloisa Reniers HR Guimarães Henrique Cerqueira HC Costa Jamille Hemétrio Salles Martins JHSM Batista Joanna d'Arc Lyra JDL Alvarenga Joice Coutinho de JC Chatkin José Miguel JM Morais Júlia Drumond Parreiras de JDP Machado-Rugolo Juliana J Ruschel Karen Brasil KB Pinheiro Lílian Santos LS Menezes Luanna Silva Monteiro LSM Couto Luciana Siuves Ferreira LSF Kopittke Luciane L Castro Luís César de LC Nasi Luiz Antônio LA Cabral Máderson Alvares de Souza MAS Floriani Maiara Anschau MA Souza Maíra Dias MD Carneiro Marcelo M Bicalho Maria Aparecida Camargos MAC Godoy Mariana Frizzo de MF Nogueira Matheus Carvalho Alves MCA Guimarães Júnior Milton Henriques MH Sampaio Natália da Cunha Severino NDCS Oliveira Neimy Ramos de NR Assaf Pedro Ledic PL Finger Renan Goulart RG Campos Roberta Xavier RX Menezes Rochele Mosmann RM Francisco Saionara Cristina SC Alvarenga Samuel Penchel SP Guimarães Silvana Mangeon Mereilles SMM Araújo Silvia Ferreira SF Oliveira Talita Fischer TF Diniz Thulio Henrique Oliveira THO Ramires Yuri Carlotto YC Cenci Evelin Paola de Almeida EPA Oliveira Thainara Conceição de TC Schwarzbold Alexandre Vargas AV Ziegelmann Patricia Klarmann PK Pozza Roberta R Carvalho Caroline Scherer CS Pires Magda Carvalho MC Marcolino Milena Soriano MS
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases 20220119
<h4>Background</h4>It is not clear whether previous thyroid diseases influence the course and outcomes of COVID-19.<h4>Methods</h4>The study is a part of a multicentric cohort of patients with confirmed COVID-19 diagnosis from 37 hospitals. Matching for age, sex, number of comorbidities, and hospital was performed for the paired analysis.<h4>Results</h4>Of 7,762 patients with COVID-19, 526 had previously diagnosed hypothyroidism and 526 were matched controls. The median age was 70 years, and 68. ...[more]
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