Dissecting and predicting different types of binding sites in nucleic acids based on structural information.

ABSTRACT: The biological functions of DNA and RNA generally depend on their interactions with other molecules, such as small ligands, proteins and nucleic acids. However, our knowledge of the nucleic acid binding sites for different interaction partners is very limited, and identification of these critical binding regions is not a trivial work. Herein, we performed a comprehensive comparison between binding and nonbinding sites and among different categories of binding sites in these two nucleic acid classes. From the structural perspective, RNA may interact with ligands through forming binding pockets and contact proteins and nucleic acids using protruding surfaces, while DNA may adopt regions closer to the middle of the chain to make contacts with other molecules. Based on structural information,

SUBMITTER: Jiang Z 

PROVIDER: S-EPMC8769709 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature