A tale of solving two computational challenges in protein science: neoantigen prediction and protein structure prediction.
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ABSTRACT:
SUBMITTER: Tran NH
PROVIDER: S-EPMC8769896 | biostudies-literature | 2022 Jan
REPOSITORIES: biostudies-literature
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A tale of solving two computational challenges in protein science: neoantigen prediction and protein structure prediction.
Tran Ngoc Hieu NH Xu Jinbo J Li Ming M
Briefings in bioinformatics 20220101 1
In this article, we review two challenging computational questions in protein science: neoantigen prediction and protein structure prediction. Both topics have seen significant leaps forward by deep learning within the past five years, which immediately unlocked new developments of drugs and immunotherapies. We show that deep learning models offer unique advantages, such as representation learning and multi-layer architecture, which make them an ideal choice to leverage a huge amount of protein ...[more]
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