5-HT_2C receptor perturbation has bidirectional influence over instrumental vigour and restraint.

ABSTRACT: The serotonin (5-HT) system, particularly the 5-HT_2C receptor, has consistently been implicated in behavioural control. However, while some studies have focused on the role 5-HT_2C receptors play in regulating motivation to work for reward, others have highlighted its importance in response restraint. To date, it is unclear how 5-HT transmission at this receptor regulates the balance of response invigoration and restraint in anticipation of future reward. In addition, it remains to be established how 5-HT_2C receptors gate the influence of internal versus cue-driven processes over reward-guided actions. To elucidate these issues, we investigated the effects of administering the 5-HT_2C receptor antagonist SB242084, both systemically and directly int

SUBMITTER: Harmson O 

PROVIDER: S-EPMC8770415 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature