Dataset Information

Fabricating Dual-Functional Plasmonic-Magnetic Au@MgFe₂O₄ Nanohybrids for Photothermal Therapy and Magnetic Resonance Imaging.

ABSTRACT: Bifunctional nanohybrids possessing both plasmonic and magnetic functionalities are of great interest for biomedical applications owing to their capability for simultaneous therapy and diagnostics. Herein, we fabricate a core-shell structured plasmonic-magnetic nanocomposite system that can serve as a dual-functional agent due to its combined photothermal therapeutic and magnetic resonance imaging (MRI) functions. The photothermal activity of the hybrid is attributed to its plasmonic Au core, which is capable of absorbing near-infrared (NIR) light and converting it into heat. Meanwhile, the magnetic MgFe₂O₄ shell exerts its ability to act as a MRI contrast agent. Our in vivo studies using tumor-bearing mice demonstrated the nanohybrids' excellent photothermal and MRI properties. As a photothermal therapeutic agent, the nanohybrids were able to dramatically shrink solid tumors in mice through NIR-induced hyperthermia. As T ₂-weighted MRI contrast agents, the nanohybrids were found capable of substantially reducing the MRI signal intensity of the tumor region at 10 min postinjection. With their dual plasmonic-magnetic functionality, these Au@MgFe₂O₄ nanohybrids hold great promise not only in the biomedical field but also in the areas of catalysis and optical sensing.

SUBMITTER: Qiu E

PROVIDER: S-EPMC8771950 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Fabricating Dual-Functional Plasmonic-Magnetic Au@MgFe<sub>2</sub>O<sub>4</sub> Nanohybrids for Photothermal Therapy and Magnetic Resonance Imaging.

Qiu Enhui E Chen Xiaofang X Yang Da-Peng DP Regulacio Michelle D MD Ramos Rufus Mart Ceasar R RMCR Luo Zheng Z Wu Yun-Long YL Lin Ming M Li Zibiao Z Loh Xian Jun XJ Ye Enyi E

ACS omega 20220107 2

Bifunctional nanohybrids possessing both plasmonic and magnetic functionalities are of great interest for biomedical applications owing to their capability for simultaneous therapy and diagnostics. Herein, we fabricate a core-shell structured plasmonic-magnetic nanocomposite system that can serve as a dual-functional agent due to its combined photothermal therapeutic and magnetic resonance imaging (MRI) functions. The photothermal activity of the hybrid is attributed to its plasmonic Au core, wh ...[more]

PMID: 35071891

Similar Datasets

Project description:BackgroundNano-photothermal therapy (NPTT) has gained wide attention in cancer treatment due to its high efficiency and selective treatment strategy. The biggest challenges in the clinical application are the lack of (i) a reliable platform for mapping the thermal dose and (ii) efficient photothermal agents (PTAs). This study developed a 3D treatment planning for NPTT to reduce the uncertainty of treatment procedures, based on our synthesized nanohybrid.MethodsThis study aimed to develop a three-dimensional finite element method (FEM) model for in vivo NPTT in mice using magneto-plasmonic nanohybrids, which are complex assemblies of superparamagnetic iron oxide nanoparticles and gold nanorods. The model was based on Pennes' bio-heat equation and utilized a geometrically correct mice whole-body. CT26 colon tumor-bearing BALB/c mice were injected with nanohybrids and imaged using MRI (3 Tesla) before and after injection. MR images were segmented, and STereoLithography (STL) files of mice bodies and nanohybrid distribution in the tumor were established to create a realistic geometry for the model. The accuracy of the temperature predictions was validated by using an infrared (IR) camera.ResultsThe photothermal conversion efficiency of the nanohybrids was experimentally determined to be approximately 30%. The intratumoral (IT) injection group showed the highest temperature increase, with a maximum of 17 °C observed at the hottest point on the surface of the tumor-bearing mice for 300 s of laser exposure at a power density of 1.4 W/cm2. Furthermore, the highest level of tissue damage, with a maximum value of Ω = 0.4, was observed in the IT injection group, as determined through a simulation study.ConclusionsOur synthesized nanohybrid shows potential as an effective agent for MRI-guided NPTT. The developed model accurately predicted temperature distributions and tissue damage in the tumor. However, the current temperature validation method, which relies on limited 2D measurements, may be too lenient. Further refinement is necessary to improve validation. Nevertheless, the presented FEM model holds great promise for clinical NPTT treatment planning.

Dataset Information

Fabricating Dual-Functional Plasmonic-Magnetic Au@MgFe₂O₄ Nanohybrids for Photothermal Therapy and Magnetic Resonance Imaging.

Publications

Fabricating Dual-Functional Plasmonic-Magnetic Au@MgFe<sub>2</sub>O<sub>4</sub> Nanohybrids for Photothermal Therapy and Magnetic Resonance Imaging.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

Dataset Information

Fabricating Dual-Functional Plasmonic-Magnetic Au@MgFe2O4 Nanohybrids for Photothermal Therapy and Magnetic Resonance Imaging.

Publications

Fabricating Dual-Functional Plasmonic-Magnetic Au@MgFe<sub>2</sub>O<sub>4</sub> Nanohybrids for Photothermal Therapy and Magnetic Resonance Imaging.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

Fabricating Dual-Functional Plasmonic-Magnetic Au@MgFe₂O₄ Nanohybrids for Photothermal Therapy and Magnetic Resonance Imaging.