Ontology highlight
ABSTRACT:
SUBMITTER: Szczerbinska I
PROVIDER: S-EPMC8773179 | biostudies-literature | 2022 Jan
REPOSITORIES: biostudies-literature
Szczerbinska Iwona I Tessitore Annamaria A Hansson Lena Kristina LK Agrawal Asmita A Ragel Lopez Alejandro A Helenius Marianne M Malinowski Andrzej R AR Gilboa Barak B Ruby Maxwell A MA Gupta Ramneek R Ämmälä Carina C
Biomedicines 20220104 1
Type 2 diabetes (T2D) is a chronic metabolic disorder affecting almost half a billion people worldwide. Impaired function of pancreatic β-cells is both a hallmark of T2D and an underlying factor in the pathophysiology of the disease. Understanding the cellular mechanisms regulating appropriate insulin secretion has been of long-standing interest in the scientific and clinical communities. To identify novel genes regulating insulin secretion we developed a robust arrayed siRNA screen measuring ba ...[more]