Ontology highlight
ABSTRACT:
SUBMITTER: Eom S
PROVIDER: S-EPMC8773328 | biostudies-literature | 2021 Dec
REPOSITORIES: biostudies-literature
Eom Sanung S Lee Bo-Bae BB Lee Shinhui S Park Youngseo Y Yeom Hye Duck HD Kim Tae-Hwan TH Nam Seung-Hee SH Lee Junho H JH
Antioxidants (Basel, Switzerland) 20211228 1
Transient receptor potential vanilloid member 1 (TRPV1) is activated in response to capsaicin, protons, temperature, and free reactive oxygen species (ROS) released from inflammatory molecules after exposure to harmful stimuli. The expression level of TRPV1 is elevated in the dorsal root ganglion, and its activation through capsaicin and ROS mediates neuropathic pain in mice. Its expression is high in peripheral and central nervous systems. Although pain is a response evolved for survival, many ...[more]