Ontology highlight
ABSTRACT:
SUBMITTER: Zhu J
PROVIDER: S-EPMC8773490 | biostudies-literature | 2022 Jan
REPOSITORIES: biostudies-literature
Zhu Jianlin J Wang Lu L Liu Fan F Pan Jinghua J Yao Zhimeng Z Lin Yusheng Y Yang Yabing Y Xiong Xiao X Li Kai K Yang Yi Y Zhang Yiran Y Chu Xiaodong X Pan Yunlong Y Zhang Hao H
Cancers 20220113 2
Abnormal angiogenesis is one of the important hallmarks of colorectal cancer as well as other solid tumors. Optimally, anti-angiogenesis therapy could restrain malignant angiogenesis to control tumor expansion. PELP1 is as a scaffolding oncogenic protein in a variety of cancer types, but its involvement in angiogenesis is unknown. In this study, PELP1 was found to be abnormally upregulated and highly coincidental with increased MVD in CRC. Further, treatment with conditioned medium (CM) from PEL ...[more]