Ontology highlight
ABSTRACT:
SUBMITTER: Nguyen M
PROVIDER: S-EPMC8774721 | biostudies-literature | 2022 Jan
REPOSITORIES: biostudies-literature
Nguyen Mimi M Sabry Reem R Davis Ola S OS Favetta Laura A LA
Genes 20220114 1
Bisphenol A (BPA) and its analogs, bisphenol S (BPS) and bisphenol F (BPF), might impact fertility by altering oxidative stress pathways. Here, we hypothesize that bisphenols-induced oxidative stress is responsible for decreased gamete quality. In both female (cumulus-oocyte-complexes-COCs) and male (spermatozoa), oxidative stress was measured by CM-H<sub>2</sub>DCFDA assay and key ROS scavengers (SOD1, SOD2, GPX1, GPX4, CAT) were quantified at the mRNA and protein levels using qPCR and Western ...[more]