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Rapid detection of mutations in the 23S rRNA gene of Helicobacter pylori that confers resistance to clarithromycin treatment to the bacterium.


ABSTRACT: We developed a new method capable of detecting point mutations in the 23S rRNA gene of Helicobacter pylori using a LightCycler. Our method can detect a mutation in this gene in less than 1 h and can process many samples at once, thereby contributing to the selection of patients suitable for clarithromycin-based therapy.

SUBMITTER: Matsumura M 

PROVIDER: S-EPMC87798 | biostudies-literature | 2001 Feb

REPOSITORIES: biostudies-literature

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Rapid detection of mutations in the 23S rRNA gene of Helicobacter pylori that confers resistance to clarithromycin treatment to the bacterium.

Matsumura M M   Hikiba Y Y   Ogura K K   Togo G G   Tsukuda I I   Ushikawa K K   Shiratori Y Y   Omata M M  

Journal of clinical microbiology 20010201 2


We developed a new method capable of detecting point mutations in the 23S rRNA gene of Helicobacter pylori using a LightCycler. Our method can detect a mutation in this gene in less than 1 h and can process many samples at once, thereby contributing to the selection of patients suitable for clarithromycin-based therapy. ...[more]

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