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An Investigation into Hydraulic Permeability of Fibrous Membranes with Nonwoven Random and Quasi-Parallel Structures.

ABSTRACT: Fibrous membranes with a nonwoven random structure and a quasi-parallel fibrous structure can be fabricated by the electrospinning technique. The membranes with different structures exhibited different behaviors to a hydraulic flow passing through the membranes. This work presents the effects of the fiber arrangement, fiber diameter, and deformations of the fibers on the hydraulic permeability. The results showed that the hydraulic flow can generate an extrusion pressure which affects the porosity and pore structure of the fibrous membranes. The quasi-parallel fibrous membranes and nonwoven membranes exhibited similar variation tendencies to the change of the experimental variables. However, the quasi-parallel fibrous membranes exhibited a higher sensibility to the change of the hydraulic flow rate. The hydraulic permeability of the quasi-parallel fibrous membranes was further analyzed with packing state models in this work.

SUBMITTER: Liu Z

PROVIDER: S-EPMC8780038 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature

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An Investigation into Hydraulic Permeability of Fibrous Membranes with Nonwoven Random and Quasi-Parallel Structures.

Liu Zeman Z Wang Yiqi Y Guo Fei F

Membranes 20211231 1

Fibrous membranes with a nonwoven random structure and a quasi-parallel fibrous structure can be fabricated by the electrospinning technique. The membranes with different structures exhibited different behaviors to a hydraulic flow passing through the membranes. This work presents the effects of the fiber arrangement, fiber diameter, and deformations of the fibers on the hydraulic permeability. The results showed that the hydraulic flow can generate an extrusion pressure which affects the porosi ...[more]

PMID: 35054580

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Project description:Drug permeability is often a limiting step in drug action, requiring chemical optimization of a drug candidate to improve this property. Such optimization is typically performed in the context of a congeneric series, where substituents are varied to optimize the target property. Motivated by this need the present work examines the influence of chemical substituents on passive permeability (log P pass) across parallel artificial membranes (PAMPA) undertaken for three congeneric series of compounds; benzoic acids, pyridines and quinolines. PAMPA showed pyridine and quinoline to have high permeability and chemical substituents to typically reduce the permeability. On the contrary, benzoic acid showed poor permeability and chemical substituents typically increased the permeability. To quantitate these effects with respect to physical properties, models were built to explain and predict the permeability of these classes of compounds based on computed molecular descriptors. Models for the benzoic acid series in the ionized state indicated the solvent accessible surface area, cavity dispersion and the free energy of solvation in hexane as well as in water to dominate permeability. However, when the acid group is treated as neutral, the free energy of solvation in water, the fraction polar surface area, the polar surface area and difference in the free energy of solvation between hexane and water were important; these terms, among others, were also important for the neutral pyridine-quinoline series. Considering that the permeability of the benzoic acid series is about 2 orders of magnitude lower than the pyridines and quinolines and that a shift of approximately two pH units in the p K a of the acid group of benzoic acid will allow for the neutral species of the molecule to dominate under experimental conditions (pH = 6.5), these results suggest that the additional energy barrier associated with permeation of the benzoic acid series is associated with the need to protonate the acidic group, thereby forming the neutral species which may then cross the hydrophobic region of the membrane.

Dataset Information

An Investigation into Hydraulic Permeability of Fibrous Membranes with Nonwoven Random and Quasi-Parallel Structures.

Publications

An Investigation into Hydraulic Permeability of Fibrous Membranes with Nonwoven Random and Quasi-Parallel Structures.

Similar Datasets

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