Bacteriophages and related endolysins for reduction of microorganisms in the human body - a systematic review.

ABSTRACT: Background: In recent years, resistance to antibiotics has become a global threat, and alternatives to antibiotics have become an area of research. The main alternative methods are briefly described in this review. However, the main focus is bacteriophage-related therapy. Bacteriophages are viruses which, due to the production of the enzyme endolysin, are able to kill bacterial host cells. Bacteriophage therapies have a long tradition. Their potential to function as antibiotics lies in their bactericidal activity and specificity in killing bacteria without infecting or affecting eukaryotic cells. Objective: To systematically review the outcomes of bacteriophage therapy in patients with bacterial infections. Methods: The MEDLINE, EMBASE, Web of Science and CENTRAL datab

SUBMITTER: Ozal D 

PROVIDER: S-EPMC8780682 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature