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Challenges and Opportunities for the Translation of Single-Cell RNA Sequencing Technologies to Dermatology.

ABSTRACT: Skin is a complex and heterogeneous organ at the cellular level. This complexity is beginning to be understood through the application of single-cell genomics and computational tools. A large number of datasets that shed light on how the different human skin cell types interact in homeostasis-and what ceases to work in diverse dermatological diseases-have been generated and are publicly available. However, translation of these novel aspects to the clinic is lacking. This review aims to summarize the state-of-the-art of skin biology using single-cell technologies, with a special focus on skin pathologies and the translation of mechanistic findings to the clinic. The main implications of this review are to summarize the benefits and limitations of single-cell analysis and thus help translate the emerging insights from these novel techniques to the bedside.

SUBMITTER: Ascension AM

PROVIDER: S-EPMC8781146 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature

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Challenges and Opportunities for the Translation of Single-Cell RNA Sequencing Technologies to Dermatology.

Ascensión Alex M AM Araúzo-Bravo Marcos J MJ Izeta Ander A

Life (Basel, Switzerland) 20220104 1

Skin is a complex and heterogeneous organ at the cellular level. This complexity is beginning to be understood through the application of single-cell genomics and computational tools. A large number of datasets that shed light on how the different human skin cell types interact in homeostasis-and what ceases to work in diverse dermatological diseases-have been generated and are publicly available. However, translation of these novel aspects to the clinic is lacking. This review aims to summarize ...[more]

PMID: 35054460

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