Bioinformatics analysis and identification of hub genes and immune-related molecular mechanisms in chronic myeloid leukemia.

ABSTRACT:

Background

Chronic myeloid leukemia (CML) is a malignant hyperplastic tumor of the bone marrow originating from pluripotent hematopoietic stem cells. The advent of tyrosine kinase inhibitors (TKIs) has greatly improved the survival rate of patients with CML. However, TKI-resistance leads to the disease recurrence and progression. This study aimed to identify immune-related genes (IRGs) associated with CML progression.

Methods

We extracted the gene's expression profiles from the Gene Expression Omnibus (GEO). Bioinformatics analysis was used to determine the differentially expressed IRGs of CML and normal peripheral blood mononuclear cells (PBMCs). Functional enrichment and gene set enrichment analysis (GSEA) were used to explore its potential mechanism. Hub genes were identi

SUBMITTER: Yao F 

PROVIDER: S-EPMC8781323 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature