Dataset Information

Nationwide COVID-19-EII Study: Incidence, Environmental Risk Factors and Long-Term Follow-Up of Patients with Inflammatory Bowel Disease and COVID-19 of the ENEIDA Registry.

ABSTRACT: We aim to describe the incidence and source of contagion of COVID-19 in patients with IBD, as well as the risk factors for a severe course and long-term sequelae. This is a prospective observational study of IBD and COVID-19 included in the ENEIDA registry (53,682 from 73 centres) between March-July 2020 followed-up for 12 months. Results were compared with data of the general population (National Centre of Epidemiology and Catalonia). A total of 482 patients with COVID-19 were identified. Twenty-eight percent were infected in the work environment, and 48% were infected by intrafamilial transmission, despite having good adherence to lockdown. Thirty-five percent required hospitalization, 7.9% had severe COVID-19 and 3.7% died. Similar data were reported in the general population (hospitalisation 19.5%, ICU 2.1% and mortality 4.6%). Factors related to death and severe COVID-19 were being aged ≥ 60 years (OR 7.1, 95% CI: 1.8-27 and 4.5, 95% CI: 1.3-15.9), while having ≥2 comorbidities increased mortality (OR 3.9, 95% CI: 1.3-11.6). None of the drugs for IBD were related to severe COVID-19. Immunosuppression was definitively stopped in 1% of patients at 12 months. The prognosis of COVID-19 in IBD, even in immunosuppressed patients, is similar to that in the general population. Thus, there is no need for more strict protection measures in IBD.

SUBMITTER: Zabana Y

PROVIDER: S-EPMC8781643 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature

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Nationwide COVID-19-EII Study: Incidence, Environmental Risk Factors and Long-Term Follow-Up of Patients with Inflammatory Bowel Disease and COVID-19 of the ENEIDA Registry.

Zabana Yamile Y Marín-Jiménez Ignacio I Rodríguez-Lago Iago I Vera Isabel I Martín-Arranz María Dolores MD Guerra Iván I Gisbert Javier P JP Mesonero Francisco F Benítez Olga O Taxonera Carlos C Ponferrada-Díaz Ángel Á Piqueras Marta M Lucendo Alfredo J AJ Caballol Berta B Mañosa Míriam M Martínez-Montiel Pilar P Bosca-Watts Maia M Gordillo Jordi J Bujanda Luis L Manceñido Noemí N Martínez-Pérez Teresa T López Alicia A Rodríguez-Gutiérrez Cristina C García-López Santiago S Vega Pablo P Rivero Montserrat M Melcarne Luigi L Calvo Maria M Iborra Marisa M Barreiro de-Acosta Manuel M Sicilia Beatriz B Barrio Jesús J Pérez José Lázaro JL Busquets David D Pérez-Martínez Isabel I Navarro-Llavat Mercè M Hernández Vicent V Argüelles-Arias Federico F Ramírez Esteso Fernando F Meijide Susana S Ramos Laura L Gomollón Fernando F Muñoz Fernando F Suris Gerard G de Zarate Jone Ortiz JO Huguet José María JM Llaó Jordina J García-Sepulcre Mariana Fe MF Sierra Mónica M Durà Miguel M Estrecha Sandra S Fuentes Coronel Ana A Hinojosa Esther E Olivan Lorenzo L Iglesias Eva E Gutiérrez Ana A Varela Pilar P Rull Núria N Gilabert Pau P Hernández-Camba Alejandro A Brotons Alicia A Ginard Daniel D Sesé Eva E Carpio Daniel D Aceituno Montserrat M Cabriada José Luis JL González-Lama Yago Y Jiménez Laura L Chaparro María M López-San Román Antonio A Alba Cristina C Plaza-Santos Rocío R Mena Raquel R Tamarit-Sebastián Sonsoles S Ricart Elena E Calafat Margalida M Olivares Sonsoles S Navarro Pablo P Bertoletti Federico F Alonso-Galán Horacio H Pajares Ramón R Olcina Pablo P Manzano Pamela P Domènech Eugeni E Esteve Maria M On Behalf Of The Eneida Registry Of Geteccu

Journal of clinical medicine 20220114 2

We aim to describe the incidence and source of contagion of COVID-19 in patients with IBD, as well as the risk factors for a severe course and long-term sequelae. This is a prospective observational study of IBD and COVID-19 included in the ENEIDA registry (53,682 from 73 centres) between March-July 2020 followed-up for 12 months. Results were compared with data of the general population (National Centre of Epidemiology and Catalonia). A total of 482 patients with COVID-19 were identified. Twent ...[more]

PMID: 35054116

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Project description:BackgroundCancer and sepsis share risk factors, and sepsis patients may have impaired immune response and increased morbidity long after intensive care. This study aimed to assess whether sepsis survivors are at increased risk for cancer. Our objective was to assess the incidence of new cancer in 1-year sepsis survivors and test the hypothesis that it is higher than that of the general population.MethodsWe obtained data on ICU admissions of adult patients from Swedish Intensive care registry (SICR) from 2005 to 2017. We included patients with an explicit ICD-10 code for sepsis for the primary ICU admission. We obtained data on cancer diagnoses (2001-2018), death (2005-2018) and emigration (2005-2018) from Cancer and Cause of death and National Patient Registry databases of the National Board of Health and Welfare; age and sex-specific cancer incidence rates in Sweden from NORDCAN registry from 2006 to 2018. One-year survivors formed the final cohort, that was followed for new cancer diagnoses until death, emigration, or end of 2018, whichever came first. The main outcome measure was standardized incidence rate ratio (SIR) to compare the incidence of cancer in 1-year sepsis survivors to that in the general population (NORDCAN). We also performed several sensitivity analyses.ResultsIn a cohort of 18,550 1-year survivors, 75,427 person years accumulated during a median follow-up (FU) of 3.36 years (IQR 1.72-5.86), 6366 (34.3%) patients died, and 1625 (8.8%) patients were diagnosed with a new cancer after a median FU of 2.51 (IQR 1.09-4.48) years. The incidence ratio of any new cancer over the whole FU was 1.31 (95% CI 1.23-1.40) for men and 1.74 (95% CI 1.61-1.88) for women. The difference in incidence rates persisted in several sensitivity analyses. The SIRs were highest in cancers of gastrointestinal tract, genital organs, and skin.Conclusion and relevanceCompared to general population, incidence of cancer is increased in 1-year sepsis survivors. Variation in the findings depending on follow-up time suggests that factors other than sepsis alone are involved. Surveillance for malignant disease may be warranted in sepsis survivors.

Dataset Information

Nationwide COVID-19-EII Study: Incidence, Environmental Risk Factors and Long-Term Follow-Up of Patients with Inflammatory Bowel Disease and COVID-19 of the ENEIDA Registry.

Publications

Nationwide COVID-19-EII Study: Incidence, Environmental Risk Factors and Long-Term Follow-Up of Patients with Inflammatory Bowel Disease and COVID-19 of the ENEIDA Registry.

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