Rational construction of controllable autoimmune diabetes model depicting clinical features.
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ABSTRACT:
SUBMITTER: Yu F
PROVIDER: S-EPMC8782301 | biostudies-literature | 2022
REPOSITORIES: biostudies-literature
Publications
Rational construction of controllable autoimmune diabetes model depicting clinical features.
Yu Fan F Zhou Xian X Jin Xiang X Zhao Shushu S Zhao Gan G Jiang Sheng S Geng Shuang S Wang Bin B
PloS one 20220121 1
Through animal models, particularly non-obesity diabetes model (NOD), pathological understandings of human autoimmune diabetes have been gained. However, features of those mouse models and the human disease are not sufficiently analogous; it is therefore not unexpected that interventions based on the mouse data fail at an alarming rate in clinical settings. An improvised model that maximally resembles the real pathological course is highly desirable. Here we devised a 'double-hit' strategy, panc ...[more]
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