Association between kidney function and incidence of dementia: 10-year follow-up of the Whitehall II cohort study.

ABSTRACT:

Background

Cognitive dysfunction is common in haemodialysis patients but whether poor kidney function in the general population is also associated with higher risk of dementia remains unclear.

Objective

To examine the association of kidney function with incident dementia in community dwelling older adults.

Design

Whitehall II prospective study.

Setting

Population-based study on 6,050 adults, mean age 65.8 in 2007-2009.

Methods

Poor kidney function, defined as estimated Glomerular Filtration Rate (eGFR) <60 ml/min/1.73 m2 in 2007-2009, and adverse change in eGFR was defined as decrease ≥4 ml/min/1.73 m2 between 2007-2009 and 2012-2013.Incident dementia was ascertained through linkage to electronic health records, and Cox regression was used to examine ass

SUBMITTER: Singh-Manoux A 

PROVIDER: S-EPMC8782607 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature