Parsing heterogeneity within dementia with Lewy bodies using clustering of biological, clinical, and demographic data.

ABSTRACT:

Background

Dementia with Lewy bodies (DLB) includes various core clinical features that result in different phenotypes. In addition, Alzheimer's disease (AD) and cerebrovascular pathologies are common in DLB. All this increases the heterogeneity within DLB and hampers clinical diagnosis. We addressed this heterogeneity by investigating subgroups of patients with similar biological, clinical, and demographic features.

Methods

We studied 107 extensively phenotyped DLB patients from the European DLB consortium. Factorial analysis of mixed data (FAMD) was used to identify dimensions in the data, based on sex, age, years of education, disease duration, Mini-Mental State Examination (MMSE), cerebrospinal fluid (CSF) levels of AD biomarkers, core features of DLB, and regional brain

SUBMITTER: Abdelnour C 

PROVIDER: S-EPMC8783432 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature