Genomic predictors of testosterone levels are associated with muscle fiber size and strength.

ABSTRACT:

Purpose

Circulating testosterone levels are a heritable trait with anabolic properties in various tissues, including skeletal muscle. So far, hundreds of single nucleotide polymorphisms (SNPs) associated with testosterone levels have been identified in nonathletic populations. The aim of the present study was to test the association of 822 testosterone-increasing SNPs with muscle-related traits (muscle fiber size, fat-free mass and handgrip strength) and to validate the identified SNPs in independent cohorts of strength and power athletes.

Methods

One hundred and forty-eight physically active individuals (47 females, 101 males) were assessed for cross-sectional area (CSA) of fast-twitch muscle fibers. Significant SNPs were further assessed for fat-free mass and handgrip stre

SUBMITTER: Guilherme JPLF 

PROVIDER: S-EPMC8783862 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature