SARS-CoV-2 infection in dialysis and kidney transplant patients: immunological and serological response.

ABSTRACT:

Background

Dialysis and kidney transplant patients with moderate-severe COVID-19 have a high mortality rate, around 30%, that is similar in the two populations, despite differences in their baseline characteristics. In these groups, the immunology of the disease has been poorly explored.

Methods

Thirty-two patients on dialysis or with kidney transplant and SARS-CoV-2 infection requiring hospitalization (COV group) were included in our study. Lymphocyte subsets, dendritic cell (DC) counts and monocyte activation were studied. SARS-CoV-2 anti-spike/anti-nucleocapsid were monitored, and baseline cytokines and chemokines were measured in 10 patients.

Results

The COV group, compared to healthy subjects and uninfected dialysis/kidney transplant controls, showed lower number

SUBMITTER: Alberici F 

PROVIDER: S-EPMC8784230 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature