Evolution of the Neocortex Through RNA-Binding Proteins and Post-transcriptional Regulation.

ABSTRACT: The human neocortex is undoubtedly considered a supreme accomplishment in mammalian evolution. It features a prenatally established six-layered structure which remains plastic to the myriad of changes throughout an organism's lifetime. A fundamental feature of neocortical evolution and development is the abundance and diversity of the progenitor cell population and their neuronal and glial progeny. These evolutionary upgrades are partially enabled due to the progenitors' higher proliferative capacity, compartmentalization of proliferative regions, and specification of neuronal temporal identities. The driving force of these processes may be explained by temporal molecular patterning, by which progenitors have intrinsic capacity to change their competence as neocortical neurogenesis proceed

SUBMITTER: Salamon I 

PROVIDER: S-EPMC8784817 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature