Association of Lipoprotein(a) With Atherosclerotic Plaque Progression.

ABSTRACT:

Background

Lipoprotein(a) [Lp(a)] is associated with increased risk of myocardial infarction, although the mechanism for this observation remains uncertain.

Objectives

This study aims to investigate whether Lp(a) is associated with adverse plaque progression.

Methods

Lp(a) was measured in patients with advanced stable coronary artery disease undergoing coronary computed tomography angiography at baseline and 12 months to assess progression of total, calcific, noncalcific, and low-attenuation plaque (necrotic core) in particular. High Lp(a) was defined as Lp(a) ≥ 70 mg/dL. The relationship of Lp(a) with plaque progression was assessed using linear regression analysis, adjusting for body mass index, segment involvement score, and ASSIGN score (a Scottish cardiovascular

SUBMITTER: Kaiser Y 

PROVIDER: S-EPMC8784819 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature