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Post-COVID-19 patients show an increased endothelial progenitor cell production.


ABSTRACT: SARS-CoV-2, the cause of COVID-19, has generated a global emergency. The endothelium is a target of SARS-CoV-2, generating endothelial dysfunction, an essential step for the development of cardiovascular complications. The number of endothelial progenitor cells acts as an indicator of vascular damage. However, its role in SARS-CoV-2 is unknown. The aim of this study was to quantify the number of endothelial colony forming cells (ECFCs) and assess for the first time if there is a significant increase after SARS-CoV-2 infection. This study also evaluates whether the number of ECFC is related to the presence of pulmonary embolism (PE), and if this increase correlates with any of the clinical parameters studied. A total of 63 subjects were recruited including 32 subjects 3-months after overcoming COVID-19 and 31 healthy controls. The results confirm the presence of vascular sequelae in post-COVID-19 patients, with an abnormal increase in the number of ECFCs in blood circulation compared to controls (2,81±2,33 vs 1,23±1,86, p=0.001). There was no difference in ECFC production in COVID-19 who presented acute PE compared to those that did not (3,21±2,49 vs 2,50±2,23, p>0.05). The appearance of ECFC colonies in COVID-19 patients was significantly related to male gender (p=0.003), the presence of systemic hypertension (p=0.01) and elevated hemoglobin levels (p=0.02) at the time of ECFC isolation and lower PaO2 levels (p=0.01) at admission. Whether these results indicate a prompt response of the patient to repair the damaged endothelium or reflect a post-infection injury that will persist in time is not known.

SUBMITTER: Poyatos P 

PROVIDER: S-EPMC8785258 | biostudies-literature |

REPOSITORIES: biostudies-literature

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