Using the COREX/BEST server to model the native-state ensemble.
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ABSTRACT:
SUBMITTER: Hilser VJ
PROVIDER: S-EPMC8785428 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Publications
Using the COREX/BEST server to model the native-state ensemble.
Hilser Vincent J VJ Whitten Steven T ST
Methods in molecular biology (Clifton, N.J.) 20140101
Protein structures under normal conditions exist as ensembles of interconverting, transient microstates. A computer algorithm known as COREX/BEST (Biology using Ensemble-based Structural Thermodynamics) was developed to model microstate structures and describe the native ensembles of proteins in statistical thermodynamic terms. This algorithm has been tested extensively and validated through experimental comparisons examining a range of biophysical and functional phenomena, such as structural co ...[more]
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