Cetylpyridinium chloride promotes disaggregation of SARS-CoV-2 virus-like particles.

ABSTRACT:

Background

SARS-CoV-2 is continuously disseminating worldwide. The development of strategies to break transmission is mandatory.

Aim of the study

To investigate the potential of cetylpyridinium chloride (CPC) as a viral inhibitor.

Methods

SARS-CoV-2 Virus Like-Particles (VLPs) were incubated with CPC, a potent surfactant routinely included in mouthwash preparations.

Results

Concentrations of 0.05% CPC (w/v) commonly used in mouthwash preparations are sufficient to promote the rupture of SARS-CoV-2 VLP membranes.

Conclusion

Including CPC in mouthwashes could be a prophylactic strategy to keep SARS-CoV-2 from spreading.

SUBMITTER: Bano-Polo M 

PROVIDER: S-EPMC8788378 | biostudies-literature |

REPOSITORIES: biostudies-literature